Our technologies and therapies treat 70 health conditions and include cardiac devices, surgical robotics, insulin pumps, surgical tools, patient monitoring systems, and more. Our Mission - to alleviate pain, restore health, and extend life - unites a global team of 90,000+ passionate people across 150 countries. Medtronic plc, headquartered in Dublin, Ireland, is the leading global healthcare technology company that boldly attacks the most challenging health problems facing humanity by searching out and finding solutions. in 2014 and is available worldwide.īold thinking. The Reveal LINQ ICM was cleared in the U.S. The STROKE AF study is a prospective, randomized study of 496 large and small vessel stroke patients across 33 centers in the U.S. "Not every ischemic stroke patient may need an ICM, but these data suggest some patients are more likely to experience AF and should be monitored more closely." "The STROKE AF Predictors analysis helps us better identify the patients who are most at-risk of unsuspected AF, which can inform stroke prevention strategies," said Schwamm. Patients with either congestive heart failure (CHF) and/or left atrial enlargement (LAE), for example, had an AF detection rate of 23.4% compared to 5% for patients with neither attribute, suggesting these patients are at greater risk of having AF. The one-year outcomes from the STROKE AF study Predictors of AF analysis recently published in JAMA Neurology, add insights for predicting AF in patients with small or large vessel ischemic strokes. While the STROKE AF study was not designed to detect or explain treatment differences, only 70% of patients with AF detected in the ICM arm were subsequently started on anticoagulation therapy-medication that helps prevent blood clots. 1 Patients with AF are at a five-fold increased risk for ischemic stroke. More than 87% of strokes are ischemic strokes, which occur when vessels that allow blood to flow to the brain are blocked. Stroke impacts more than 795,000 people every year. AF is a risk that we can't afford to miss for patients who have already suffered a stroke - the consequences could be devastating." "Importantly, these outcomes underscore the criticality of long-term monitoring with ICMs in these patients as much of the AF detected would have been missed at 30 days. Miller Fisher endowed chair in vascular neurology and professor of Neurology at Massachusetts General Hospital and Harvard Medical School. Schwamm, M.D., chief digital advisor, Mass General Brigham, C. "What these data show us is that we can't always rely on patients to tell us they are having palpitations or irregular heartbeats because the majority of AF detected in the study was asymptomatic," said Lee H. The study also showed that 67% of patients (31 out of 46) in the ICM arm had clinically relevant AF episodes lasting more than one hour in duration, while 88% of AF episodes were asymptomatic. At three years, the rate of AF detection increased to 21.7% of patients in the ICM arm compared to 2.4% in the control arm, resulting in a statistically significant hazard ratio of 10 (95% CI 4.0-25.2, p<0.001). Over the first year, 12.5%* of patients in the ICM arm had AF detected compared to 1.8% of patients randomized to standard of care (consisting of external cardiac monitoring such as 12-lead ECGs, Holter monitoring, telemetry, or event recorders). The latest results, presented today as a late-breaking clinical trial at the American Stroke Association's International Stroke Conference (ISC) 2023, build on the STROKE AF study 12-month primary endpoint results published in JAMA in June 2021. 8, 2023 / PRNewswire/ - Medtronic (NYSE: MDT) today announced late-breaking clinical data from the STROKE AF clinical study, which showed large and small vessel disease stroke patients had a 10-fold increase in AF detection with the Reveal LINQ™ insertable cardiac monitor (ICM) at three years compared to patients randomized to standard of care who did not receive continuous, long-term monitoring. ISC23: Late-breaking results from STROKE AF study reinforce importance of long-term continuous cardiac monitoring in ischemic stroke patientsĭUBLIN and DALLAS, Feb.
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